The Symptoms + Complications of Multiple Myeloma

Multiple myeloma can affect the body in a multitude of ways.

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Multiple myeloma is a cancer of the plasma cell, which is a type of white blood cell. These cells live in the bone marrow and are key for healthy immune system function. Normally, those white blood cells make antibodies to help fight off infection.

“In myeloma, [the plasma cells] misbehave and start making an antibody that’s completely useless,” says Adriana Rossi, MD, associate clinical director of the Myeloma Center at Weill Cornell Medicine and NewYork-Presbyterian.

This abnormal antibody, called M protein, floats around and can be toxic to kidneys or attack other parts of the body, she says.

“So instead of helping you fight an infection, the [abnormal plasma cells] just sort of accumulate,” says Dr. Rossi. These “misbehaving” cells then crowd out the normal, infection-fighting plasma cells, which can lead to low blood counts and low immune cells. The change in blood cells can affect the body in different ways.

Bone symptoms

“Lesions in the bones tend to lead to bone pain,” said Dr. Rossi. “About 80 percent of patients will come up with some sort of bone pain.”

Patients may feel bone pain in the back or chest, or less commonly, the arms and legs, at the time of diagnosis. Patients may also experience bone loss throughout the body which can lead to osteoporosis and fractures. (Learn more about what happens to your body during osteoporosis.)


Anemia is a condition in which you don't have enough healthy red blood cells to carry oxygen to your body's tissues. It can cause paleness, weakness, and fatigue.

Impaired kidney function

The excess proteins and high blood calcium levels that may come with multiple myeloma can damage the kidneys and lead to kidney failure.

Decreased kidney function doesn’t often show symptoms until it’s escalated to kidney failure, says Dr. Rossi. “Spilling proteins can cause foam in the urine, so that's something that [they may] notice.”

“The good news is that most of the time, if the kidney failure is due to myeloma, we can reverse it entirely,” says Dr. Rossi.

Nerve problems

Multiple myeloma can affect the nerves in different ways. “The antibodies that are floating around can directly attack nerves,” says Dr Rossi. Symptoms may include odd sensations (numbness or tingling), pain, or muscle weakness.

Multiple myeloma in the spine, however, can have more severe complications. “[It can] push up against the spinal cord and cause constant back pain and pain that radiates down the legs or causes weakness in the legs. That is a medical emergency that requires immediate attention,” says Dr. Rossi.


Multiple myeloma patients don’t have a fully functional immune system, so they’re much more likely to get infections, says Dr. Rossi. Pneumonia is a common and serious infection seen in myeloma patients.

“There are ways to support the patient's immune system,” says Dr. Rossi. “If they are not able to make their own antibodies, [we can provide] antibodies from other healthy individuals to keep infections at bay.”

How to Manage Multiple Myeloma Symptoms

“The best way to alleviate symptoms due to multiple myeloma is to treat the disease itself,” says Dr. Rossi. “Anti-myeloma therapy tends to be very effective in recovering kidney function, building up your blood counts, and decreasing your bone pain.”

“It's important for everyone to have a good relationship with their primary care doctor and bring up any concerns that they have,” says Dr. Rossi.