Diabetes Oral Drug Treatment Guide


If you are working to control your blood sugar due to Type 2 diabetes, your doctor may recommend the oral medication Onglyza. Our Pharmacist reviews

If you are working to control your blood sugar due to Type 2 diabetes, your doctor may recommend the oral medication Onglyza. The generic name of Onglyza is Saxagliptin. Onglyza is a dipeptidyl peptidase 4 inhibitor that works in two ways. First, Onglyza increases the production of insulin in the pancreas. Insulin helps the body’s cells absorb sugar from the blood for energy. Second, Onglyza decreases the release of stored sugar by the liver. By doing these two things, Onglyza can lower blood sugar in those with Type 2 diabetes.

Before starting treatment with Onglyza, tell your doctor about any allergies to food or medicine, if you are pregnant or planning to become pregnant, if you have any other medical conditions such as an acidic blood problem, and discuss any other medications and supplements you are taking.

Onglyza comes in pill form and is usually taken once a day with or without food. Take the pill whole without chewing or crushing it, and if you miss a dose take it immediately. However if it is close to the time of your next scheduled dose, skip the missed pill and get back on track with the next dose. Don’t take double doses.

During your treatment with Onglyza, continue to check your blood sugar and get blood work done regularly as recommended by your doctor. Keep in mind that it may more difficult to regulate your blood sugar if you are sick or have a fever or infection.

Call your doctor if you experience any of these side effects: allergic reactions, changes in urination or signs of pancreatitis. Symptoms of pancreatitis include severe stomach or back pain, upset stomach or vomiting. Other potential side effects of Onglyza are low blood sugar, headache, sore throat, and a stuffy or runny nose.


It is important to follow your treatment with Onglyza as prescribed by your doctor, and let your doctor know if you are experiencing any problems with it. 

Punkaj Khanna, Pharm. D.

This video features Punkaj Khanna, Pharm. D.. Punkaj Khanna earned his Pharm.D. from Massachusetts College of Pharmacy. He works at Memorial Sloan-Kettering Cancer Center, and has special interests in patient education and compliance.

Duration: 2:39. Last Updated On: July 25, 2018, 10:52 a.m.
Reviewed by: Dr Helen Maliagros Scott, Preeti Parikh, MD . Review date: July 25, 2018
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